Poor Kidney Function Linked to Future Stroke, Cardiovascular Disease


Poor kidney function, even at the earliest stages, portends a greater risk for stroke and cardiovascular disease, according to 2 studies published online October 1 in the BMJ.

In the first, a meta-analysis of 33 prospective studies comprising 284,672 subjects, a low glomerular filtration rate at baseline was independently related to incident stroke.

And in the second, a prospective, population-based cohort study of almost 17,000 people, even the earliest stages of chronic kidney disease were associated with an excess risk for subsequent coronary heart disease (CHD).

According to the first article, observational studies and a recent meta-analysis showed that a low estimated glomerular filtration rate (eGFR) was associated with an increased risk for CHD and all-cause and cardiovascular mortality in the general population. However, the effect of a reduced eGFR on incident stroke is not well delineated.

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