Collateral Flow Effect on Stroke Risk Modified by Stenosis Severity

Eleanor McDermid

The presence of collateral blood flow modifies patients' stroke risk differently according to the severity of intracranial atherosclerosis, shows an analysis of the WASID trial.

David Liebeskind (University of California, Los Angeles, USA) and colleagues found that good collaterals reduced the risk for stroke in patients with severe stenosis, but were a marker of increased stroke risk among those with milder stenosis.

"The influential role of collateral circulation alters prior predictive models and substantiates the consideration of angiographic features in future studies of intracranial atherosclerosis," the researchers write in the Annals of Neurology.

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